Personally it worked on me! My crowfeet and wrinkles between my eyebrows are thinner. I don't really see much effect for the wrinkles on my forehead though... I'm not very concerned about my smile lines yet, but I apply some cream for prevention. According to the beauty advisor, you should apply the cream perpendicular to the skin so I move my finger along the wrinkles. Retinol irritates my skin often, so I'm glad this serum is gentle.
Wrinkle Shot Medical Serum
Milk Lotion & Serum
Eye & Lip Care
This medicated beauty serum combines NEI - L1, an active ingredient to treat the production of wrinkles and will also improve the appearance of wrinkles. In addition, we have developed the NEI - L1 dermal penetration prescription to effectively deliver active ingredients to the dermis. It suppresses "neutrophil elastase" and improve wrinkles. Apply on skin after lotion every morning and night to the corners of the eyes, mouth, forehead and on any area with wrinkles. Gently blend with the skin and stretch the wrinkles outwards and up. (OTC product)